A BRIEF REVIEW OF ANALYTICAL METHODS FOR THE ESTIMATION OF TTR KINETIC STABILIZERS IN PHARMACEUTICAL FORMULATIONS AND BIOLOGICAL MATRICES
نویسندگان
چکیده
Transthyretin kinetic stabilizers are used as first-line drug therapy for transthyretin amyloid polyneuropathy mostly in patients unsuitable liver transplantation. The two drugs prescribed clinical practice Tafamidis and Diflunisal. European Medicines Agency approved this prescription 2011 2019 American Food Drug Association also registered it the same use. Diflunisal is a non-steroidal anti-inflammatory but its structural similarities to determine “off-label” use such conditions. This review article represents various analytical methods available published literature determination of bulk drugs, pharmaceutical formulations, biological matrices. Detailed information about all developed quantitative consisting spectrophotometry, spectrofluorimetry, high-performance liquid chromatography with ultraviolet, fluorescence or diode array detection, chromatography-tandem mass spectrometry, voltammetry provided can be effectively development new procedures routine manufacturing practice.
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ژورنال
عنوان ژورنال: International Journal of Applied Pharmaceutics
سال: 2022
ISSN: ['0975-7058']
DOI: https://doi.org/10.22159/ijap.2022v14i5.45612